. Defects of innate immunity .

Invasive Bacterial Infections, Predisposition panel [6 genes]

Predisposition to invasive bacterial infections is a PID characterized by defects in genes involved in bacterial sensing and anti-bacterial effector pathways, including the Toll and Toll-IL-1R pathways of cytokine and interferon (IFN) induction. These pathways are important for innate recognition of pyogenic and gram-negative bacteria.

Clinical features

  • Pyogenic infections
  • Meningitis, arthritis, septicemia
  • No fever
  • Resistant to other infections
  • Onset: infancy


  • Rare
  • Few families described

Service benefits and management

  • Genetic diagnosiis and counselling
  • Immunoglobulin replacement (IVIG)
  • Prophylactic antibiotics


This website uses cookies for the best user experience. If you continue browsing you are giving your consent for the acceptance of the aforementioned cookies and acceptance of our cookies policy, click on the link for more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.